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The Role of Hyposthenuria in Enuresis Among Paediatric Patients With Sickle Cell Disease

Jasim N Al-Asadi1, Alyaa M Radhi2, Dhuha S Jumaa2

  • 1Departments of Family & Community Medicine.

Sultan Qaboos University Medical Journal
|June 28, 2023
PubMed

Insights

Enuresis is common in children with sickle cell disease (SCD). This study found hyposthenuria, a kidney concentrating defect, to be a significant risk factor for enuresis in these children.

Area of Science:

  • Pediatric Nephrology
  • Hematology
  • Urology

Background:

  • Enuresis (bedwetting) is a frequent issue in children with sickle cell disease (SCD).
  • The relationship between enuresis and hyposthenuria (impaired urine concentrating ability) in SCD patients remains debated.
  • Understanding risk factors is crucial for managing enuresis in this vulnerable population.

Purpose of the Study:

  • To determine the prevalence of enuresis among children with SCD in Basrah, Iraq.
  • To investigate the association between enuresis and hyposthenuria in children with SCD.
  • To identify other potential risk factors for enuresis in this cohort.

Main Methods:

  • A cross-sectional study involving 161 children with SCD was conducted in Basrah, Iraq.
  • Data on enuresis, sociodemographic factors, and clinical variables were collected via questionnaire.
  • Urine specific gravity was measured to assess for hyposthenuria, and logistic regression identified risk factors.

Main Results:

  • Enuresis was present in 31.1% of the studied children with SCD.
  • Independent risk factors for enuresis included a family history of enuresis (OR=5.94), hyposthenuria (OR=3.76), and sleep disorders (OR=2.90).
  • The study found a significant association between hyposthenuria and enuresis in children with SCD.

Conclusions:

  • Enuresis is a common condition among children with sickle cell disease in Basrah, Iraq.
  • Hyposthenuria is significantly associated with enuresis in children with SCD.
  • Family history of enuresis and sleep disorders are also important risk factors to consider.
Abstract

Keywords:
ChildrenEnuresisIraqPrevalenceSickle Cell Disease

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