Pd-catalyzed intermolecular consecutive double Heck reaction "on water" under air: facile synthesis of substituted
Dong Wei1,2,3, Han-Yu Lu3, Han-Zhe Miao3
1State Key Laboratory of Systems Medicine for Cancer, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200127 China laoniulyb@shsmu.edu.cn.
Abstract:
An efficient and environmentally benign method for the preparation of substituted indene derivatives has been developed by using water as the sole solvent. This reaction proceeded under air, tolerated a wide range of functional-groups and was easily scaled up. Bioactive natural products like indriline were synthesized via the developed protocol. Preliminary results demonstrate that the enantioselective variant can also be achieved.
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