Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elongational flow response of compressible polymer melts.

The Journal of chemical physics·2026
Same author

Shape elasticity in colloidal bent-core liquid crystals.

Soft matter·2026
Same author

From Coils to Rods: Structure and Dynamics of Polyelectrolytes in Water.

ACS macro letters·2026
Same author

Analytical interaction potentials for disks in two dimensions.

The Journal of chemical physics·2026
Same author

Intermediate time sub-diffusion and stress relaxation in ring polymer melts.

The Journal of chemical physics·2026
Same author

Probing Nanorod Assembly and Dynamics in Polymer Nanocomposites in Equilibrium and Shear.

Macromolecules·2026

Related Experiment Video

Updated: Jul 25, 2025

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
07:31

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis

Published on: July 16, 2020

6.0K

Polydots, soft nanoparticles, at membrane interfaces.

Sidath Wijesinghe1, Christoph Junghans2, Dvora Perahia1

  • 1Department of Chemistry, Clemson University Clemson South Carolina 29634 USA dperahi@g.clemson.edu.

RSC Advances
|June 28, 2023
PubMed
Summary

Soft nanoparticles, or polydots, can cross cell membranes without damage. Their interaction with membranes can be controlled by surface charge, crucial for targeted drug delivery and imaging in nanomedicine.

More Related Videos

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
10:06

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Published on: September 2, 2022

1.9K
Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

7.0K

Related Experiment Videos

Last Updated: Jul 25, 2025

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
07:31

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis

Published on: July 16, 2020

6.0K
Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
10:06

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Published on: September 2, 2022

1.9K
Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

7.0K

Area of Science:

  • Nanomedicine
  • Biophysics
  • Materials Science

Background:

  • Soft nanoparticles (NPs) show promise for nanomedicine applications like drug delivery and imaging.
  • Understanding NP-membrane interactions is vital for their safe and effective use in biological systems.

Purpose of the Study:

  • To investigate the interaction of soft polymer nanoparticles (polydots) with a model cell membrane.
  • To determine how surface charge affects polydot translocation across membranes.

Main Methods:

  • Atomistic molecular dynamics (MD) simulations were employed.
  • Simulations focused on polydots made of dialkyl para-phenylene ethylene (PPE) with varying carboxylate groups interacting with a dipalmitoyl phosphatidylcholine (DPPC) membrane.

Main Results:

  • Polydots maintained their structure when interacting with the membrane.
  • Neutral polydots spontaneously permeated the membrane.
  • Carboxylated polydots required a force dependent on their surface charge for membrane penetration, with minimal membrane disruption.

Conclusions:

  • Polydot behavior at membrane interfaces is governed by physical forces and tunable via surface charge.
  • These findings offer a method to control nanoparticle positioning for therapeutic applications in nanomedicine.