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Drug induced nephrotoxicity- A mechanistic approach
Veerta Sharma1, Thakur Gurjeet Singh2
1Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India, 140401.
Molecular Biology Reports
|June 28, 2023
Summary
Drug nephrotoxicity is a significant pharmacotherapy complication. This review covers drug-induced kidney injury mechanisms, common nephrotoxic drugs, and biomarkers for managing this adverse effect.
Area of Science:
- Pharmacology
- Nephrology
- Toxicology
Background:
- Patient treatment effectiveness and safety are paramount.
- Adverse drug effects are an inherent risk of pharmacotherapy.
- The kidney's role in drug elimination makes it vulnerable to drug-induced injury.
Purpose of the Study:
- To review the pathogenic mechanisms of drug-induced nephrotoxicity.
- To identify common drugs with nephrotoxicity potential.
- To discuss renal biomarkers for drug-related kidney damage.
Main Methods:
- Literature review of pathogenic mechanisms.
- Identification of drugs with known nephrotoxicity.
- Summary of current renal biomarkers for drug-induced kidney damage.
Main Results:
- Drug nephrotoxicity is a significant complication of pharmacotherapy.
- No universally accepted definition or diagnostic criteria for drug-induced nephrotoxicity exist.
- Specific drugs carry a higher risk of kidney injury.
Conclusions:
- Understanding drug nephrotoxicity mechanisms is crucial.
- Awareness of nephrotoxic drugs aids in risk mitigation.
- Renal biomarkers are essential for managing drug-related kidney damage.
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