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Related Experiment Video

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Whole Vitreous Humor Dissection for Vitreodynamic Analysis

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[Age-related changes in human vitreous].

V A Shaimova^1,2, S Kh Kuchkildina², G R Islamova²

¹Academy of Postgraduate Education of the Federal Scientific and Clinical Center of Specialized Types of Medical Care and Medical Technologies, Moscow, Russia.

Vestnik Oftalmologii

|June 28, 2023

Summary

Age-related changes like liquefaction and aggregation cause posterior vitreous detachment (PVD). This review details PVD progression, emphasizing its potential peripheral onset and anomalous forms impacting the retina.

Keywords:

optical coherence tomography posterior vitreous detachment vitreous body

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Area of Science:

Ophthalmology and Vision Science
Gerontology
Biomedical Engineering

Context:

Age-related changes in the vitreous humor, including liquefaction (synchesis) and syneresis, are fundamental to understanding vitreoretinal interface dynamics.
Posterior vitreous detachment (PVD) is a common consequence of these age-related vitreous alterations.
Existing classifications of PVD often rely on morphological features or pathogenesis, with recent advancements influenced by Optical Coherence Tomography (OCT).

Purpose:

To review the physiological and anomalous progression of posterior vitreous detachment (PVD).
To highlight the distinct stages of age-related PVD and its potential starting points.
To discuss the implications of anomalous PVD on retinal and vitreous health due to vitreoretinal traction.

Summary:

Vitreous liquefaction and collagen aggregation are key age-related changes leading to posterior vitreous detachment (PVD).
PVD can follow a normal, staged progression driven by aging or an anomalous course.
The review underscores that PVD may initiate peripherally before affecting the posterior pole and can cause detrimental tractional effects.

Impact:

Provides a comprehensive overview of PVD, aiding clinicians in diagnosis and management.
Enhances understanding of PVD pathogenesis, potentially leading to novel therapeutic strategies.
Contributes to the literature on age-related ocular changes and their impact on vision.