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Intranasal trigeminal function in chronic rhinosinusitis: a review.
Anna Kristina Hernandez1,2,3, Thomas Hummel1
1Smell and Taste Clinic, Department of Otorhinolaryngology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Expert Review of Clinical Immunology
|June 28, 2023
Summary
Chronic rhinosinusitis (CRS) impacts intranasal trigeminal sensitivity, affecting quality of life. Understanding this link is crucial for better CRS symptom management and treatment strategies.
Area of Science:
- Otolaryngology
- Neuroscience
- Immunology
Background:
- Chronic rhinosinusitis (CRS) affects 5-12% of the population, significantly impacting quality of life.
- Chronic inflammation in CRS is increasingly recognized to affect intranasal trigeminal sensitivity.
- The interplay between olfaction and trigeminal nerve function is synergistic and may be disrupted in CRS.
Purpose of the Study:
- To systematically review and summarize current knowledge on intranasal trigeminal function in patients with chronic rhinosinusitis.
- To explore the relationship between trigeminal dysfunction and CRS symptoms, assessment, and treatment.
- To identify gaps in understanding and suggest future research directions.
Main Methods:
- A systematic literature search was conducted in February 2023.
- Databases searched included Scopus, Web of Science, and PubMed.
- The review focused on studies investigating intranasal trigeminal function in the context of CRS.
Main Results:
- Trigeminal dysfunction may contribute to the perception of nasal obstruction in CRS, beyond physical blockage.
- Potential mechanisms for trigeminal dysfunction include immune-mediated nerve damage and altered nerve growth factor.
- The pathophysiology of trigeminal dysfunction in CRS is not well understood.
Conclusions:
- Current treatments for CRS primarily address the underlying inflammation, with unclear effects on trigeminal function.
- Further research is needed to elucidate the mechanisms of trigeminal dysfunction in CRS.
- Development of standardized clinical trigeminal tests is recommended for future studies.
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