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Related Concept Videos

Dementia01:30

Dementia

142
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
142
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

530
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Amnesia01:13

Amnesia

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Amnesia is a condition marked by long-term memory loss, which impairs the ability to recall past events or create new memories.
The severity and duration of memory loss vary depending on the type and underlying cause. Amnesia is classified into two main types: retrograde and anterograde.
Retrograde amnesia is marked by the loss of memories formed before the onset of the condition. Patients may recall distant past events but often forget those occurring shortly before the incident.
Anterograde...
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Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

501
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
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Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

222
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

607
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Related Experiment Video

Updated: Jul 25, 2025

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

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Frontotemporal dementia: Past, present, and future.

Hulya Ulugut1,2, Yolande A L Pijnenburg1

  • 1Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|June 28, 2023
PubMed
Summary
This summary is machine-generated.

Frontotemporal dementia (FTD) has a long history but was only recently recognized as a distinct neurological condition. Understanding its evolution is key to developing future therapies and diagnostic tools.

Keywords:
behavioral sciencesdementiadementia of the frontal typefrontal lobe dementiafrontotemporal dementiahistoryneuropsychiatrypick's disease and frontotemporal lobar degeneration

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Area of Science:

  • Neurology
  • Neuroscience
  • Psychiatry

Background:

  • Frontotemporal dementia (FTD) has historical roots tracing back to the 19th century.
  • Its recognition as a distinct neurological entity is a more recent development, occurring only a few decades ago.

Purpose of the Study:

  • To explore the historical background, evolution, and future directions of frontotemporal dementia (FTD).
  • To provide an overview of the challenges and advancements in understanding and diagnosing FTD.

Main Methods:

  • Qualitative study and literature review.
  • Analysis of historical perceptions, diagnostic challenges, and scientific advancements related to FTD.

Main Results:

  • Recognition of FTD was historically impeded by rigid dementia perceptions, disciplinary divides, assessment limitations, and lack of pathological evidence.
  • Overcoming barriers involved re-examining early work, focusing on focal impairments, creating non-Alzheimer's cohorts, and fostering collaboration.
  • Current challenges include the need for biology-oriented psychiatry education, biomarkers, and objective diagnostic instruments.

Conclusions:

  • Independent multidisciplinary centers are crucial for FTD research and care.
  • The future of FTD involves developing disease-modifying therapies, offering new avenues for professionals and researchers.