Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Converging metabolic and functional networks for tremor expression and deep brain stimulation-mediated control.

NPJ Parkinson's disease·2026
Same author

StimVision: smartphone video kinematics to optimize DBS programming in Parkinson's disease.

NPJ Parkinson's disease·2026
Same author

Localizing beta synchronous neurons in the STN using directional DBS recordings and patient-specific biophysical models.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same author

Probabilistic mapping of tremor control and gait ataxia risk in deep brain stimulation.

Journal of neural transmission (Vienna, Austria : 1996)·2026
Same author

Model-based design of subthalamic nucleus neurons using hybrid optimization.

Journal of neurophysiology·2026
Same author

Neuroimaging and Pathology Biomarkers in Parkinson's Disease and Parkinsonism.

Brain sciences·2026

Related Experiment Video

Updated: Jul 25, 2025

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
10:52

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Published on: October 2, 2015

19.8K

Quantifying the Variability Associated with Postoperative Localization of Deep Brain Stimulation Electrodes.

Kelsey L Bower1, Angela M Noecker1, Martin M Reich2

  • 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.

Stereotactic and Functional Neurosurgery
|June 28, 2023
PubMed
Summary

Accurate deep brain stimulation (DBS) electrode localization is crucial for computational models. This study quanties the variability in DBS electrode placement across different imaging registration methods, highlighting the need to account for this uncertainty in clinical research.

Keywords:
CTMRIRegistrationSubthalamic nucleus

More Related Videos

Operative Technique and Nuances for the Stereoelectroencephalographic SEEG Methodology Utilizing a Robotic Stereotactic Guidance System
04:50

Operative Technique and Nuances for the Stereoelectroencephalographic SEEG Methodology Utilizing a Robotic Stereotactic Guidance System

Published on: June 9, 2023

3.7K
Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging
09:33

Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging

Published on: November 15, 2024

1.3K

Related Experiment Videos

Last Updated: Jul 25, 2025

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
10:52

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Published on: October 2, 2015

19.8K
Operative Technique and Nuances for the Stereoelectroencephalographic SEEG Methodology Utilizing a Robotic Stereotactic Guidance System
04:50

Operative Technique and Nuances for the Stereoelectroencephalographic SEEG Methodology Utilizing a Robotic Stereotactic Guidance System

Published on: June 9, 2023

3.7K
Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging
09:33

Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging

Published on: November 15, 2024

1.3K

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Computational Biology

Background:

  • Computational models of deep brain stimulation (DBS) are vital for correlating stimulation sites with behavioral outcomes.
  • Accurate localization of DBS electrodes within patient-specific anatomy, typically via CT and MRI co-registration, is essential for model reliability.
  • Existing registration approaches can lead to variations in estimated electrode positions.

Purpose of the Study:

  • To investigate the impact of different image processing steps on DBS electrode localization accuracy.
  • To quantify the uncertainty in DBS electrode placement arising from various registration techniques.
  • To inform statistical analyses in DBS mapping studies by understanding localization variability.

Main Methods:

  • Co-registration of long-term postoperative CT and preoperative surgical targeting MRI datasets from 10 subthalamic DBS subjects.
  • Utilized 9 different registration approaches to estimate DBS electrode locations.
  • Calculated the distances between electrode location estimates derived from each approach.

Main Results:

  • Across different registration methods, DBS electrodes were localized within a median distance of 0.57 mm.
  • Using short-term postoperative CT scans increased the median distance to 2.01 mm, indicating greater variability.
  • Significant differences in electrode localization estimates were observed based on the chosen registration strategy.

Conclusions:

  • Electrode location uncertainty is a critical factor that must be incorporated into statistical analyses for DBS mapping studies.
  • The choice of image registration and processing steps significantly influences DBS electrode localization.
  • Addressing this uncertainty can improve the robustness and accuracy of findings in DBS research correlating stimulation with clinical outcomes.