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Updated: Jul 25, 2025

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Polydimethylsiloxane-polycarbonate Microfluidic Devices for Cell Migration Studies Under Perpendicular Chemical and Oxygen Gradients
Published on: February 23, 2017
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[Study on Migrants Found in Migration Solutions from Commercially Available Polyethylene Products]
Keiko Iwakoshi1, Katsushi Iwakoshi1, Megumi Hasebe1
1Tokyo Metropolitan Institute of Public Health.
Summary
Migrants from polyethylene food packaging were analyzed. Irganox 1076 was found below EU limits, confirming safe migration levels in plastic bags.
Area of Science:
- Analytical Chemistry
- Food Safety Science
- Polymer Science
Context:
- Polyethylene (PE) products are widely used for food packaging.
- Chemical migration from food contact materials (FCMs) is a regulatory concern.
- Accurate analytical methods are crucial for assessing food safety.
Purpose:
- To investigate migrants in polyethylene food packaging.
- To quantify specific substances using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
- To develop and validate an analytical approach using a retention gap for enhanced separation.
Summary:
- Non-target screening and targeted quantification of 14 substances were performed on migration solutions from commercial PE products.
- Irganox 1076 was detected in nine tested plastic bags at a maximum of 1.5 mg/kg, which is one-fourth of the European Union's Specific Migration Limit (SML).
- Migration of Erucamide and Irgafos 168-oxide was also confirmed, adhering to European Regulation No 10/2011/EU.
Impact:
- The study confirms the safety of commonly used polyethylene food packaging concerning specific chemical migrants.
- Validated analytical methods provide reliable tools for regulatory compliance and food safety monitoring.
- Findings support the ongoing assessment of migration from food contact materials into foodstuffs.
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