Esophageal organoids: applications and future prospects

Area of Science:

• Biomedical research
• Organoid technology
• Disease modeling

Background:

• Organoids are advanced 3D cell culture models that mimic organ structures and functions.
• Esophageal organoids provide a more reliable alternative to traditional 2D cell lines and animal models for studying esophageal conditions.
• Recent advancements include diverse cell sources and established protocols for esophageal organoid development.

Purpose of the Study:

• To review the development of tumor and non-tumor esophageal organoids.
• To summarize current applications in disease modeling, regenerative medicine, and drug screening.
• To discuss future prospects of esophageal organoid technology.

Main Methods:

• Development of esophageal organoids from various cell sources.
• Establishment of organoid models for esophageal adenocarcinoma, squamous cell carcinoma, and eosinophilic esophagitis.
• Integration of organoids with other technologies like organ chips and xenografts.

Main Results:

• Esophageal organoids accurately mimic native esophageal cell biology and disease pathology.
• Established models for esophageal inflammation and cancer show high reliability.
• Organoid properties facilitate drug screening and regenerative medicine applications.

Conclusions:

• Esophageal organoids represent a significant advancement in biomedical research, offering superior reliability.
• Their application in modeling diseases and testing therapeutics is expanding.
• Future integration with other technologies promises novel research models, particularly for cancer research.