Related Experiment Video
Updated: Jul 25, 2025
06:34
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
4.0K
Plasma Proteomic Patterns Show Sex Differences in Early Concentric Left Ventricular Remodeling
Anne-Mar van Ommen1, Ernest Diez Benavente1, N Charlotte Onland-Moret2
1Laboratory of Experimental Cardiology (A.-M.v.O., E.D.B., G.B.V., H.M.d.R.), University Medical Center Utrecht, Utrecht University, the Netherlands.
Circulation. Heart Failure
|June 29, 2023
Summary
Concentric remodeling (cRM) affects about 1 in 4 women and men, increasing heart failure with preserved ejection fraction (HFpEF) and mortality risk. Inflammatory pathways and IFNA5 are key in women, suggesting new therapeutic targets.
Area of Science:
- Cardiology
- Cardiovascular Research
- Proteomics
Background:
- Concentric remodeling (cRM) is a precursor to heart failure with preserved ejection fraction (HFpEF).
- HFpEF is notably prevalent in women.
- Understanding cRM's development and risk factors is crucial for cardiovascular health, especially in women.
Purpose of the Study:
- To investigate the prevalence of cRM in a large outpatient cardiology population.
- To determine the association of cRM with HFpEF development and mortality.
- To identify sex-specific risk factors and molecular pathways involved in cRM.
Main Methods:
- Analysis of 60,593 patients from outpatient cardiology clinics for cRM, HFpEF, and mortality.
- Sex-stratified analysis of risk factors for relative wall thickness.
- Proteomic profiling of 4,534 plasma proteins in a 557-patient substudy to identify pathways involved in cRM.
Main Results:
- cRM was found in 23.5% of women and 27.6% of men, linked to increased HFpEF risk (HR 2.15) and mortality (HR 1.09).
- Risk factors for relative wall thickness were stronger in women.
- Elevated IFNA5 levels and activated inflammatory pathways were observed in women with cRM.
Conclusions:
- cRM is a common condition associated with adverse cardiovascular outcomes in both sexes.
- Sex differences in risk factors and inflammatory pathway activation, particularly involving IFNA5 in women, may explain HFpEF's female predominance.
- These findings offer potential for novel therapeutic strategies targeting cRM and HFpEF prevention and treatment.
