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THC-O-Acetate: Scarce Evidence for a Psychedelic Cannabinoid.

Daniel J Kruger^1,2, Carlton Cb Bone³, Meredith C Meacham³

¹Population Studies Center, University of Michigan, Ann Arbor, MI, USA.

Journal of Psychoactive Drugs

|June 29, 2023

Summary

This summary is machine-generated.

THC-O-acetate (THC-Oac) does not produce psychedelic effects, according to a new study. Most users reported minimal cognitive distortions and few visual hallucinations, with prior psychedelic users reporting even less intense experiences.

Keywords:

Cannabinoid Cannabis Psychedelic THC-O-acetate THCO

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Area of Science:

Pharmacology
Psychology
Cannabinoid Research

Background:

Semi-synthetic cannabinoids, such as THC-O-acetate (THC-Oac), are gaining attention.
Claims suggest THC-Oac may induce psychedelic effects, but scientific examination is lacking.

Purpose of the Study:

This study is the first to investigate the claim that THC-Oac produces psychedelic effects.
To assess the subjective experiential profile of THC-Oac consumption.

Main Methods:

An online survey was developed for THC-Oac consumers, incorporating elements from validated cannabis and psychedelic use questionnaires.
The Mystical Experience Questionnaire (MEQ) was included to quantify psychedelic experience characteristics.

Main Results:

Participants reported low to moderate cognitive distortions and minimal visual or hallucinatory experiences.
THC-Oac consumption did not meet the threshold for a complete mystical experience across all MEQ dimensions.
Individuals with prior classic psychedelic use reported significantly lower MEQ scores.

Conclusions:

The study found no evidence that THC-Oac produces psychedelic effects.
Reported psychedelic experiences may be influenced by user expectations or product contaminants.
Previous psychedelic use was associated with diminished subjective experiences of THC-Oac.