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On the conversion of verapamil to carboxy verapamil
Research Communications in Chemical Pathology and Pharmacology
|June 1, 1986
Abstract:
The reaction of verapamil with concentrated sulfuric acid was studied. It was found, in disagreement with a published report, that the reaction did not hydrolyze the nitrile group of the drug to the corresponding carboxylic acid, but, instead, produced a sulfonated derivative. Analysis of the product using several spectroscopic techniques indicated that the sulfonic acid moiety was introduced into the verapamil molecule at the 6-position of the 3,4-dimethoxyphenyl ring distant to the chiral center.