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Updated: Jul 25, 2025
09:54
A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
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Sleep apnea and cardiovascular risk.
Manu Rajachandran1, Nils Nickel, Richard A Lange
1Department of Internal Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, Texas, USA.
Current Opinion in Cardiology
|June 29, 2023
Summary
Obstructive sleep apnea (OSA) significantly impacts cardiovascular health, increasing risks for hypertension and heart disease. Understanding its links to endothelial dysfunction and atherothrombotic disease is crucial for prevention.
Area of Science:
- Cardiology
- Sleep Medicine
- Pathophysiology
Background:
- Obstructive sleep apnea (OSA) is increasingly recognized for its substantial impact on cardiovascular health.
- It is strongly associated with major cardiovascular risk factors and conditions, including hypertension, coronary artery disease, congestive heart failure, and sudden cardiac death.
Conclusions:
- The cardiovascular effects of OSA result from a complex interplay of hypoxic oxidative stress, autonomic dysregulation, endothelial damage, and inflammation.
- Further research is needed to fully elucidate the pathophysiological relationship between OSA and cardiovascular disease.
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