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Updated: Jul 25, 2025
06:58
Global Identification of Co-Translational Interaction Networks by Selective Ribosome Profiling
Published on: October 7, 2021
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Molecular Highway Patrol for Ribosome Collisions
Kaushik Viswanathan Iyer1, Max Müller1, Lena Sophie Tittel1
1Institute for Pharmaceutical and Biomedical Sciences, Johannes Gutenberg-University Mainz, Staudingerweg 5, 55128, Mainz, Germany.
Chembiochem : a European Journal of Chemical Biology
|June 29, 2023
Summary
Ribosome collisions during translation can cause toxic proteins linked to neurodegeneration. Cells have evolved pathways to rescue collided ribosomes and manage translation stress, protecting against disease.
Area of Science:
- Molecular Biology
- Cell Biology
- Neuroscience
Background:
- Ribosomes decode messenger RNAs (mRNAs) during protein synthesis.
- Ribosome stalling, caused by various factors, can lead to collisions with trailing ribosomes.
- Collisions may produce aberrant proteins, contributing to diseases like neurodegeneration.
Purpose of the Study:
- To summarize current knowledge on pathways that rescue collided ribosomes.
- To outline cellular stress responses triggered by ribosome collisions.
- To highlight the role of these pathways in preventing disease.
Main Methods:
- Review of existing literature on ribosome collisions and cellular responses.
- Analysis of eukaryotic and bacterial pathways for ribosome rescue.
- Examination of stress response mechanisms activated by translation stress.
Main Results:
- Eukaryotes and bacteria possess distinct pathways to resolve ribosome collisions.
- Ubiquitin ligases are key in eukaryotic ribosome rescue complexes.
- Ribosome collisions activate cellular stress responses, including translation inhibition and immune modulation.
Conclusions:
- Ribosome collision rescue and stress response pathways are crucial for cellular homeostasis.
- Dysfunctional pathways can lead to protein aggregation and neurodegenerative diseases.
- Understanding these pathways offers insights into disease mechanisms and potential therapeutic targets.
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