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Association between polymorphisms in connexin 40 gene (Cx40) and risk of atrial fibrillation: a meta-analysis based

Zheng Lian1, Zheng Ma1, Zhi-Li Zhang1

  • 1Cardiovascular Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
|June 29, 2023
PubMed

Insights

Connexin 40 (Cx40) gene polymorphisms are linked to an increased risk of atrial fibrillation (AF). This meta-analysis confirms a positive association, particularly for the Cx40 -44 polymorphism, across diverse populations.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Cardiology
  • Genetics of Cardiac Arrhythmias

Background:

  • Atrial fibrillation (AF) is a prevalent arrhythmia linked to severe outcomes like stroke and heart failure, yet its underlying causes remain incompletely understood.
  • Previous research on the association between connexin 40 (Cx40) gene polymorphisms and AF risk has yielded conflicting results, necessitating further investigation.

Approach:

  • A comprehensive meta-analysis was conducted, synthesizing data from 12 English and Chinese studies.
  • Odds ratios (OR) and 95% confidence intervals (CI) were calculated to assess the genetic association between Cx40 polymorphisms and AF risk.
  • Studies focused on two specific Cx40 polymorphisms: -44 (rs35594137) and -26 (rs10465885).

Key Points:

  • The meta-analysis identified a significant association between the Cx40 -44 polymorphism and an increased risk of AF across five genetic models and in both Asian and non-Asian subgroups.
  • The Cx40 -26 polymorphism showed an increased risk of AF in the dominant model overall, with a significant association found in the recessive genetic model specifically within the Asian population.
  • These findings suggest a positive correlation between Cx40 polymorphisms and AF susceptibility.

Conclusions:

  • Connexin 40 (Cx40) polymorphisms are significantly associated with an elevated risk of developing atrial fibrillation (AF).
  • The Cx40 -44 polymorphism demonstrates a particularly strong positive association with AF risk in both Asian and non-Asian populations.
  • This meta-analysis provides robust evidence supporting the role of Cx40 genetic variations in the pathogenesis of atrial fibrillation.
Abstract

Keywords:
AFAtrial fibrillationconnexin 40 (Cx40)meta-analysispolymorphism

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