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Updated: Jul 25, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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Published on: April 22, 2019

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Nivolumab for Advanced Hepatocellular Carcinoma with Multiple Lung Metastases after Sorafenib Failure

Jaewoong Kim1, Jin Won Chang1, Jun Yong Park1,2,3

  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Journal of Liver Cancer
|June 29, 2023
PubMed

Insights

Advanced hepatocellular carcinoma (HCC) patients who failed transarterial chemoembolization and sorafenib achieved complete response with nivolumab. This immunotherapy offers a promising second-line treatment option for advanced HCC.

Area of Science:

  • Hepatocellular Carcinoma Research
  • Medical Oncology
  • Immunotherapy

Background:

  • Sorafenib has been the standard first-line systemic treatment for advanced hepatocellular carcinoma (HCC) for a decade.
  • Regorafenib is the only globally approved second-line therapy for HCC after sorafenib progression.
  • Immunotherapy is emerging as a significant treatment modality for various cancers, including advanced HCC.

Observation:

  • A case of advanced HCC with multiple lung metastases is presented.
  • The patient had previously failed transarterial chemoembolization and sorafenib treatments.
  • Nivolumab was administered as a second-line therapy post-sorafenib failure.

Findings:

  • Complete response was achieved in the patient with advanced HCC and lung metastases.
  • The patient maintained progression-free status following nivolumab treatment.
  • Nivolumab demonstrated efficacy in a difficult-to-treat HCC case.

Implications:

  • This case report suggests nivolumab's potential as an effective second-line treatment for advanced HCC.
  • The findings may support the expanded clinical application of nivolumab in HCC management.
  • Immunotherapy represents a valuable therapeutic avenue for patients with advanced HCC refractory to standard treatments.
Keywords:
Hepatocellular carcinomaImmunotherapyLung metastasisNivolumabSorafenib failure

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