Related Experiment Video
Updated: Jul 25, 2025
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
20.0K
Kikuchi-Fujimoto disease: A comprehensive review
Vikram K Mahajan1, Vikas Sharma2, Neeraj Sharma2
1Department of Dermatology, Venereology and Leprosy, Dr. Radhakrishnan Government Medical College, Hamirpur 177001, Himachal Pradesh, India. vkm1@rediffmail.com.
World Journal of Clinical Cases
|June 29, 2023
Summary
Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting lymph node disorder affecting young adults. Diagnosis requires careful histopathology, as KFD can mimic other conditions like lymphoma and lupus.
Area of Science:
- Immunology
- Pathology
- Rheumatology
Background:
- Kikuchi-Fujimoto disease (KFD) is a rare, benign, self-limiting necrotizing lymphadenitis of unknown cause.
- It primarily affects young adults, presenting with fever and lymphadenopathy, and can have cutaneous manifestations.
- KFD shares a complex relationship with systemic lupus erythematosus (SLE) and is often misdiagnosed.
Purpose of the Study:
- To review the clinicoepidemiological, diagnostic, and management aspects of KFD.
- To highlight the diagnostic challenges and differential diagnoses of KFD.
- To provide insights for practicing clinicians managing KFD.
Main Methods:
- Review of clinicoepidemiological data.
- Analysis of diagnostic modalities, including histopathology.
- Evaluation of current management strategies.
Main Results:
- KFD presents with fever and lymphadenopathy, with variable cutaneous involvement in 30-40% of cases.
- Differential diagnoses include lymphoma, SLE, and infectious lymphadenitis.
- Fine needle aspiration cytology is often nonspecific; histopathology is diagnostic.
Conclusions:
- Accurate diagnosis of KFD relies on careful histopathological evaluation of lymph node biopsies.
- Early biopsy is crucial to avoid unnecessary investigations and empirical treatments.
- Management, often empirical, may involve corticosteroids or hydroxychloroquine.
Related Concept Videos
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
226
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
226
01:30Inflammatory Bowel Disease II: Crohn's Disease
303
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
303
01:17Chronic Bowel Disorders: Introduction
490
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
490
01:26Nephrotic Syndrome II : Assessment and Medical Management
10
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
10
01:24Nephrotic Syndrome I : Introduction
10
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
10
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
199
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
199