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Bone Density Reduction and Its Associated Factors in Kidney Transplant Recipients: A Cross-Sectional Study
B Gheiasi1, M Hadavi1, R Asadzadeh1
1Department of Internal Medicine, School of Medicine, Shahid Mostafa Khomeini Hospital, Ilam University of Medical Sciences, Ilam, Iran.
International Journal of Organ Transplantation Medicine
|June 29, 2023
Summary
Kidney transplant recipients often experience decreased bone mineral density (BMD). Prednisolone use, age, and vitamin D levels are key factors influencing osteoporosis risk in these patients.
Area of Science:
- Nephrology
- Endocrinology
- Orthopedics
Background:
- Decreased bone mineral density (BMD) is a common complication following kidney transplantation.
- Factors contributing to BMD reduction are numerous, but research findings remain inconsistent.
Purpose of the Study:
- To determine the prevalence of reduced BMD in kidney transplant recipients.
- To identify factors associated with BMD reduction in this patient population.
Main Methods:
- A study included 69 kidney transplant recipients between 2016-2018.
- Bone mineral density (BMD) was assessed using dual-energy X-ray absorptiometry.
- Statistical analyses included logistic regression to identify risk factors.
Main Results:
- Overall osteoporosis prevalence was 38% in the femur and 32% in the lumbar spine.
- In younger patients (<50 years), osteoporosis was linked to vitamin D levels and sex.
- In older patients (>50 years), osteoporosis risk increased with age and duration of prednisolone use.
Conclusions:
- Prednisolone consumption is a significant factor in BMD reduction post-kidney transplant.
- Regular BMD monitoring and minimizing prednisolone dosage are crucial for prevention.
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