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Updated: Jul 25, 2025
Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
Published on: March 7, 2022
A bibliometric analysis of myocardial ischemia/reperfusion injury from 2000 to 2023
Yifei Wang1,2, Lijun Guo1,3, Zhibo Zhang1,2
1Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Background:
Myocardial ischemia/reperfusion injury (MIRI) refers to the more severe damage that occurs in the previously ischemic myocardium after a short-term interruption of myocardial blood supply followed by restoration of blood flow within a certain period of time. MIRI has become a major challenge affecting the therapeutic efficacy of cardiovascular surgery.
Methods:
A scientific literature search on MIRI-related papers published from 2000 to 2023 in the Web of Science Core Collection database was conducted. VOSviewer was used for bibliometric analysis to understand the scientific development and research hotspots in this field.
Results:
A total of 5,595 papers from 81 countries/regions, 3,840 research institutions, and 26,202 authors were included. China published the most papers, but the United States had the most significant influence. Harvard University was the leading research institution, and influential authors included Lefer David J., Hausenloy Derek J., Yellon Derek M., and others. All keywords can be divided into four different directions: risk factors, poor prognosis, mechanisms and cardioprotection.
Conclusion:
Research on MIRI is flourishing. It is necessary to conduct an in-depth investigation of the interaction between different mechanisms and multi-target therapy will be the focus and hotspot of MIRI research in the future.
Insights
Myocardial ischemia/reperfusion injury (MIRI) research is rapidly advancing. Future studies will focus on understanding MIRI mechanisms and developing multi-target therapies for improved cardiovascular surgery outcomes.
Area of Science:
- Cardiology
- Biomedical research
Background:
- Myocardial ischemia/reperfusion injury (MIRI) causes significant damage after restoring blood flow.
- MIRI poses a major challenge to the effectiveness of cardiovascular surgery.
Purpose of the Study:
- To analyze the scientific development and research hotspots of MIRI.
- To identify key trends and future directions in MIRI research.
Main Methods:
- Bibliometric analysis of MIRI-related papers published from 2000 to 2023.
- Utilized Web of Science Core Collection database and VOSviewer software.
Main Results:
- Included 5,595 papers from 81 countries, 3,840 institutions, and 26,202 authors.
- China led in publications; the United States showed the most influence.
- Identified four research directions: risk factors, prognosis, mechanisms, and cardioprotection.
Conclusions:
- MIRI research is a dynamic and expanding field.
- Future research emphasis will be on the interplay of MIRI mechanisms.
- Multi-target therapies are anticipated to be a key focus in MIRI research.
