Related Experiment Video

Updated: Jul 25, 2025

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.2K

Clinical progress of anti-angiogenic targeted therapy and combination therapy for gastric cancer

Donghan Xu1, Yehao Luo2, Peng Wang1

  • 1Faculty of Chinese Medicine, Macau University of Science and Technology, Macao, Macao SAR, China.

Frontiers in Oncology
|June 29, 2023
PubMed

Insights

Anti-angiogenic targeted therapies show promise for advanced gastric cancer, improving treatment outcomes. This review evaluates key drugs like Ramucirumab and Bevacizumab, offering insights into their efficacy and safety.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Gastric cancer incidence is rising, with many diagnoses at advanced stages and poor prognoses.
  • Current treatments for advanced gastric cancer remain unsatisfactory.
  • Angiogenesis is a critical factor in tumor growth, making anti-angiogenic therapies a focus.

Purpose of the Study:

  • To comprehensively evaluate the efficacy and safety of anti-angiogenic targeted drugs in gastric cancer.
  • To review drugs used alone and in combination.
  • To identify response biomarkers and discuss challenges and solutions for anti-angiogenic therapy.

Main Methods:

  • Systematic literature search and review of prospective clinical trials.
  • Analysis of data on Ramucirumab, Bevacizumab, Apatinib, Fruquintinib, Sorafenib, Sunitinib, and Pazopanib.
  • Summary of response biomarkers, challenges, and solutions.

Main Results:

  • Efficacy and safety data for various anti-angiogenic drugs in gastric cancer were summarized.
  • Key response biomarkers were identified.
  • Challenges and potential solutions for anti-angiogenic therapy were discussed.

Conclusions:

  • Anti-angiogenic targeted therapies represent a significant area of research for gastric cancer treatment.
  • Further clinical research and optimized therapeutic strategies are needed.
  • This review provides a reference for future clinical studies on anti-angiogenic drugs for gastric cancer.
Keywords:
anti-angiogenicclinical progressgastric cancerresponse biomarkertyrosine kinase inhibitor

More Related Videos

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

775
Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

7.3K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K