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BIOCHEMICAL PREDICTORS OF ENTEROCOLITIS IN CHILDREN WITH COLORECTAL ANOMALIES POST COLOSTOMY AT UNIVERSITY COLLEGE
O O Ogundoyin1,2, D I Olulana1,2, K I Egbuchulem1
1Division of Paediatric Surgery, University College Hospital, Ibadan.
Insights
Calprotectin and C-reactive protein did not predict enterocolitis in children with colorectal anomalies. Blood and plasma viscosity showed low sensitivity and predictive value for enterocolitis post-surgery.
Area of Science:
- Pediatric Surgery
- Biochemistry
- Inflammatory Markers
Background:
- Enterocolitis often persists post-surgery in children with colorectal anomalies.
- Biochemical markers like Calprotectin, CRP, and viscosity are explored for inflammation.
- Understanding reliable predictors is crucial for managing post-operative enterocolitis.
Purpose of the Study:
- To evaluate Calprotectin, CRP, blood, and plasma viscosity as biochemical predictors of enterocolitis.
- To determine the sensitivity and reliability of these markers in pediatric patients post-colorectal surgery.
- To assess their utility in predicting persistent or developing enterocolitis.
Main Methods:
- Observational analytic study of 32 pediatric patients with Hirschsprung's disease or Anorectal malformation.
- Recorded demographic data, clinical condition, and pre/postoperative biochemical analyte readings.
- Statistical analysis performed using SPSS v.23 to test for associations.
Main Results:
- Calprotectin and C-reactive protein did not predict enterocolitis in this cohort.
- Blood and plasma viscosity showed a positive correlation with each other.
- Blood viscosity had low sensitivity (66%) and a low Positive Predictive Value (25%) for enterocolitis.
Conclusions:
- Calprotectin and C-reactive protein are unreliable predictors of enterocolitis in these pediatric patients.
- Blood and plasma viscosity demonstrated limited predictive capability for enterocolitis.
- Despite marker limitations, over 90% of patients had satisfactory outcomes.
Background:
A large proportion of patients with preoperative enterocolitis still have enterocolitis persisting even after surgery while others resolve thereafter. Some researchers have studied Calprotectin, C-reactive protein (CRP), Blood and Plasma viscosity as markers of inflammation, hence, the choice of their use. The aim of the study is to determine the sensitivity and reliability of Calprotectin, C-reactive protein (CRP), Blood and Plasma viscosity as biochemical predictors of enterocolitis in children with colorectal anomaly post-surgery at University College Hospital Ibadan.
Patients And Methods:
This is an observational analytic study of 32 patients with either Hirschsprung's disease or Anorectal malformation carried out over a year period. The demographic data of the patients, clinical condition and the preoperative and postoperative readings of the biochemical analytes were recorded in a chart. Statistical analysis were carried out using SPSS version 23 and test for statistical association done.
Results:
The incidence of Hirschsprung associated enterocolitis is 12.5% and for Ano rectal malformation 6.3 %. Gender difference was not statistically significant even with the observed clinical difference. Plasma viscosity and blood viscosity correlate positively with each order. C-reactive Protein and Calprotectin did not predict enterocolitis in this study and the Sensitivity of blood viscosity at T1 and T2 is as low as 66% with a Positive Predictive Value of 25 %.
Conclusion:
The incidence of Enterocolitis associated with Hirschsprung's disease and Anorectal malformation is 19 %. Calprotectin and C-reactive protein did not predict enterocolitis in this patients. The outcome of care was satisfactory in over 90 % of the patients.
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