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Updated: Jul 25, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Interaction between ferric carboxymaltose and denosumab causing severe hypocalcaemia and hypophosphataemia in a
Jaidyn Muhandiramge1,2, Vivian Lee2, Monica Tran2
1School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Abstract:
Coadministration of ferric carboxymaltose and denosumab may cause hypocalcaemia and hypophosphataemia; however, this interaction is not well-described in the literature and has typically been described in patients with chronic kidney disease (CKD). We present a case of this interaction in a patient without preexisting CKD. We suggest the use of alternative iron preparations and an interval of at least 4 weeks between administrations.
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