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Liver dysfunction in haemophilia.

M M Steven, M Small, A Pettigrew

    Scottish Medical Journal
    |April 1, 1986
    PubMed
    Summary
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    Liver dysfunction in hemophilia patients is common but often not linked to hepatitis B infection. Abnormal liver function tests in hemophilia appear unrelated to hepatitis history or specific treatment factors.

    Area of Science:

    • Hematology
    • Hepatology
    • Virology

    Background:

    • Hemophilia patients may be at increased risk for liver dysfunction.
    • Hepatitis B infection is a potential concern in this population due to blood product exposure.

    Purpose of the Study:

    • To investigate the prevalence and causes of liver dysfunction in hemophilia patients.
    • To determine the relationship between liver function abnormalities and hepatitis B infection or treatment history.

    Main Methods:

    • Studied liver function in 139 hemophilia patients (classical hemophilia, Christmas disease, von Willebrand's disease).
    • Collected data on jaundice, hepatitis history, hepatitis B surface antibody (HBsAb) presence, and serum aminotransferase levels.
    • Reviewed five-year liver function test results for 57 patients.

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    Main Results:

    • 58% of patients had elevated serum aminotransferases, but only 6% showed persistently abnormal results over five years.
    • Liver dysfunction was not correlated with a history of hepatitis, positive HBsAb tests, age, hemophilia type, factor levels, or treatment frequency.
    • Most liver abnormalities were not clinically evident.

    Conclusions:

    • Abnormal liver function in hemophilia patients is often not attributable to past or current hepatitis B infection.
    • The cause of liver dysfunction in hemophilia may not be a single transmitted infectious agent.