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Murine Colitis Modeling using Dextran Sulfate Sodium DSS
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium DSS

Published on: January 19, 2010

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Triclocarban exposure aggravates dextran sulfate sodium-induced colitis by deteriorating the gut barrier function and

Mengyu Qin1, Hehua Lei2, Yuchen Song3

  • 1College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan 430074, China; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Centre for Magnetic Resonance in Wuhan, Innovation Academy of Precision Measurement Science and Technology, CAS, Wuhan 430071, China.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|June 29, 2023
PubMed

Insights

Triclocarban (TCC) exposure worsens colitis by damaging the gut barrier and altering microbiota. This antibacterial agent may pose environmental health risks, potentially contributing to inflammatory bowel disease and colon cancer.

Area of Science:

  • Environmental Health
  • Gastroenterology
  • Microbiology

Background:

  • Triclocarban (TCC) is a common antibacterial agent in personal care products.
  • Its enterotoxicity mechanisms and impact on gut health are not well understood.
  • Potential public health concerns exist due to its widespread use and toxicity.

Purpose of the Study:

  • To investigate the effects of TCC exposure on a dextran sulfate sodium (DSS)-induced colitis mouse model.
  • To elucidate the mechanisms underlying TCC-induced enterotoxicity.
  • To assess TCC's impact on intestinal barrier function, gut microbiota, and colonic inflammation.

Main Methods:

  • Utilized a DSS-induced colitis mouse model.
  • Employed 16S rRNA gene sequencing for gut microbiota analysis.
  • Conducted metabolomics, histopathology, and biological examinations.
  • Assessed intestinal barrier integrity and inflammatory markers.

Main Results:

  • TCC exposure aggravated colitis, shortening colon length and altering histopathology.
  • TCC disrupted intestinal barrier function, reducing goblet cells, mucus, and tight junction proteins (MUC-2, ZO-1, E-cadherin, Occludin).
  • Gut microbiota composition, SCFAs, and tryptophan metabolites were altered; colonic inflammation was exacerbated via NF-κB activation.

Conclusions:

  • TCC exposure significantly worsens colitis in mice.
  • TCC compromises intestinal barrier integrity and alters gut microbial metabolism.
  • TCC may be an environmental hazard contributing to inflammatory bowel disease and colon cancer.
Keywords:
EnterotoxicityGut microbiotaIntestinal barrier functionNF-κB pathwayTriclocarban

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