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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

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Research progress on animal models of contrast-induced acute kidney injury

Ke Deng1, Mingxin Pei2, Yanling Chen3

  • 1Department of Pathophysiology, Zhuhai Campus of Zunyi Medical University, Zhuhai Guangdong 519041, China. 3072342434@qq.com.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|June 29, 2023
PubMed

Insights

Contrast-induced acute kidney injury (CI-AKI) is a significant cause of hospital-acquired renal failure. Further research into CI-AKI pathogenesis is crucial for developing effective prevention strategies.

Area of Science:

  • Nephrology
  • Radiology
  • Cardiology

Background:

  • Contrast-induced acute kidney injury (CI-AKI) is a frequent complication following intravascular contrast media administration.
  • CI-AKI represents the third leading cause of acute renal failure in hospitalized patients.
  • Severe CI-AKI can lead to significant renal impairment, adverse cardiovascular events, and mortality.

Purpose of the Study:

  • To investigate the complex and not yet fully elucidated pathogenesis of CI-AKI.
  • To highlight the importance of understanding CI-AKI mechanisms for effective prevention.
  • To emphasize the need for robust animal models for CI-AKI research.

Main Methods:

  • This study focuses on the theoretical and experimental significance of understanding CI-AKI.
  • It underscores the necessity of developing and utilizing appropriate animal models.
  • The research involves reviewing existing literature on CI-AKI pathogenesis.

Main Results:

  • The pathogenesis of CI-AKI remains incompletely understood.
  • Effective prevention strategies are hampered by the lack of complete etiological knowledge.
  • The development of suitable animal models is identified as a critical step.

Conclusions:

  • Understanding the pathogenesis of CI-AKI is vital for its prevention.
  • Further research is essential to elucidate the mechanisms underlying CI-AKI.
  • Advanced animal models are indispensable tools for advancing CI-AKI research.

Keywords:
animal modelscontrast-induced acute kidney injuryrenal impairment

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