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Updated: Jul 25, 2025

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
Published on: February 7, 2015
MR Imaging of Carotid Artery Atherosclerosis: Updated Evidence on High-Risk Plaque Features and Emerging Trends
J C Benson1, L Saba2, G Bathla3
1From the Departments of Radiology (J.C.B., G.B., W.B.) benson.john3@mayo.edu.
Abstract:
MR imaging is well-established as the criterion standard for carotid artery atherosclerosis imaging. The capability of MR imaging to differentiate numerous plaque components has been demonstrated, including those features that are associated with a high risk of sudden changes, thrombosis, or embolization. The field of carotid plaque MR imaging is constantly evolving, with continued insight into the imaging appearance and implications of various vulnerable plaque characteristics. This article will review the most up-to-date knowledge of these high-risk plaque features on MR imaging and will delve into 2 major emerging topics: the role of vulnerable plaques in cryptogenic strokes and the potential use of MR imaging to modify carotid endarterectomy treatment guidelines.
Insights
Magnetic resonance (MR) imaging is the gold standard for detecting carotid artery atherosclerosis. Advanced MR imaging techniques identify vulnerable plaque features, aiding in stroke risk assessment and potentially guiding treatment decisions.
Area of Science:
- Neuroimaging
- Cardiovascular Imaging
- Radiology
Background:
- Carotid artery atherosclerosis is a significant risk factor for stroke.
- Magnetic resonance (MR) imaging is the established standard for evaluating carotid artery disease.
- Identifying vulnerable plaque components is crucial for predicting stroke risk.
Purpose of the Study:
- To review current knowledge on high-risk carotid plaque features identified by MR imaging.
- To discuss the emerging role of vulnerable plaques in cryptogenic strokes.
- To explore the potential of MR imaging in modifying carotid endarterectomy guidelines.
Main Methods:
- Review of current literature on MR imaging of carotid plaque.
- Analysis of imaging features associated with plaque vulnerability.
- Discussion of clinical implications and emerging applications.
Main Results:
- MR imaging can differentiate various carotid plaque components, including high-risk features.
- Specific plaque characteristics on MR imaging correlate with increased risk of adverse events.
- Emerging research highlights the link between vulnerable plaques and cryptogenic strokes.
Conclusions:
- MR imaging provides critical insights into carotid plaque vulnerability.
- Understanding these features can improve stroke risk stratification.
- MR imaging may influence future treatment strategies for carotid artery disease.
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