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Anesthesia and cancer recurrence: an overview
Etrusca Brogi1, Francesco Forfori2
1Department of Anesthesia and Intensive Care, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy. etrusca.brogi@uslnordovest.toscana.it.
Journal of Anesthesia, Analgesia and Critical Care
|June 29, 2023
Summary
Perioperative factors, including anesthesia, can suppress the immune system, potentially impacting cancer recurrence. Increased awareness is crucial for informed anesthetic choices in cancer care.
Area of Science:
- Oncology
- Immunology
- Anesthesiology
Background:
- Perioperative factors can dysregulate the immune system, potentially influencing cancer progression and metastasis.
- Anesthetics and analgesics may modulate immune responses, inflammation, and angiogenesis, affecting cancer outcomes.
- The hypothalamic-pituitary-adrenal axis and sympathetic nervous system are implicated in perioperative immunosuppression.
Purpose of the Study:
- To provide an overview of the relationship between anesthesia and cancer recurrence.
- To review the impact of surgery, perioperative factors, and anesthetic agents on tumor cell survival and recurrence.
Main Methods:
- Literature review on perioperative factors, anesthesia, and cancer recurrence.
- Analysis of the effects of anesthetic agents on immune and inflammatory systems.
- Examination of the influence on angiogenesis and tumor cell survival.
Main Results:
- Perioperative factors can lead to immune suppression, potentially promoting cancer growth.
- Anesthetic agents may influence innate and adaptive immunity, inflammation, and angiogenesis.
- Current data on anesthesia's impact on cancer recurrence are controversial but warrant attention.
Conclusions:
- Anesthesia and perioperative management significantly influence the immune system and may affect cancer recurrence.
- Further research and increased healthcare professional awareness are needed for optimal anesthetic choices in cancer patients.
- Understanding these interactions is vital for improving long-term outcomes in cancer survivors.
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