Hydrolysable tannins as a potential therapeutic drug for the human fibrosis-associated disease

Area of Science:

• Natural product chemistry
• Pathology
• Pharmacology

Background:

• Fibrosis is a pathological process involving abnormal tissue repair, leading to organ damage, failure, and significant mortality.
• Current therapeutic options for fibrotic diseases remain limited despite comprehensive understanding of their pathogenesis.
• Natural products are emerging as a promising therapeutic avenue for managing fibrosis due to their diverse beneficial properties.

Purpose of the Study:

• To review the biological activities and therapeutic potential of hydrolysable tannins (HT) in treating organ fibrosis.
• To elucidate the mechanisms by which HT inhibit fibrotic processes.
• To explore the prospects of HT as a novel strategy for fibrosis management.

Main Methods:

• Literature review focusing on hydrolysable tannins and their effects on fibrotic diseases.
• Analysis of studies detailing the biological activities of HT.
• Examination of research on the molecular mechanisms underlying HT's anti-fibrotic effects.

Main Results:

• Hydrolysable tannins exhibit various biological activities relevant to combating fibrosis.
• HT demonstrate potential in mitigating fibrosis through mechanisms including anti-inflammation, antioxidant effects, and inhibition of epithelial-mesenchymal transition.
• HT can modulate fibroblast activation, proliferation, and extracellular matrix accumulation.

Conclusions:

• Hydrolysable tannins represent a viable natural product-based strategy for the treatment of organ fibrosis.
• Understanding the detailed mechanisms of HT action provides a foundation for developing new therapeutic interventions.
• HT hold promise for the prevention and attenuation of fibrosis progression, offering a novel therapeutic avenue.