Related Experiment Video
Updated: Jul 25, 2025
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Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
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CYLD in health and disease
José L Marín-Rubio1, Ishier Raote2, Joseph Inns1
1Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
Disease Models & Mechanisms
|June 30, 2023
Summary
The CYLD deubiquitinase regulates key cellular pathways involved in immunity and cancer. CYLD"s diverse roles are illuminated by studying its various forms and mutations in both animal models and human diseases.
Area of Science:
- Biochemistry and Molecular Biology
- Cell Biology
- Genetics and Disease
Background:
- CYLD lysine 63 deubiquitinase (CYLD) is a crucial ubiquitin hydrolase implicated in immune responses and cancer development.
- CYLD's function is complex, influenced by complete ablation, truncation, and alternative isoforms, impacting inflammation, cell death, cell cycle, and transformation.
- CYLD regulates critical cellular signaling pathways, including NF-κB, Wnt, and TGF-β.
Conclusions:
- CYLD deubiquitinase is a multifaceted protein with critical roles in cellular homeostasis and disease pathogenesis.
- Understanding CYLD's regulatory mechanisms and its diverse functions in different disease contexts is essential.
- Further research into CYLD variants and their associated phenotypes will advance therapeutic strategies for cancer, neurodegeneration, and inflammatory conditions.
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