Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Other Nuclides: 31P, 19F, 15N NMR01:16

Other Nuclides: 31P, 19F, 15N NMR

418
Many organic, inorganic, and biological molecules contain spin-half nuclei such as nitrogen-15, fluorine-19, and phosphorus-31. As a result, NMR studies of these nuclei have found extensive applications in chemical and biological research.
While fluorine-19 and phosphorous-31 have high natural abundances (100%) and positive gyromagnetic ratios, nitrogen-15 has a low natural abundance and a negative gyromagnetic ratio. However, nitrogen-15 is still preferred over nitrogen-14 (which has a...
418
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

5.3K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polycationic Biocidal Coatings: The Mechanism of Their Interaction with Cells.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

The Spermidine Synthase Gene as a Reporter of Transcription Inhibition in <i>Escherichia coli</i>.

International journal of molecular sciences·2026
Same author

Novel π-extended cationic meso-arylporphyrins as photosensitizers for photodynamic therapy: Synthesis, photoinduced toxicity and in vivo fluorescence.

Journal of photochemistry and photobiology. B, Biology·2026
Same author

The first pyrido[1,2-a]benzimidazole-fused porphyrazine photosensitizers with submicromolar photodynamic activity against cancer cells.

European journal of medicinal chemistry·2026
Same author

Targeting autophagy via mitochondrial uncoupling: Discovery of novel serratin derivative as a potential therapeutic for Parkinson's disease.

Biochimie·2025
Same author

Phospho-Switch: Regulation of the Activity of SAM-Dependent Methyltransferases Using <i>H</i>-Phosphinic SAM Analogue.

International journal of molecular sciences·2025

Related Experiment Video

Updated: Jul 25, 2025

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
09:57

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography

Published on: January 11, 2020

7.5K

High-Contrast and Fast-Removable 19 F-MRI Labels with Perfluoro-tert-Butyl Substituents.

Lev L Gervits1, Andrey L Sigan1, Alina A Markova2

  • 1Division of Organoelement Compounds, A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Vavilova Street 28, bld. 1., 119334, Moscow, Russia.

Chemmedchem
|June 30, 2023
PubMed
Summary

New fluorine-19 MRI (19F MRI) labels offer high contrast and rapid elimination in vivo. These novel perfluoro-tert-butyl compounds show promise for advanced imaging applications without ionizing radiation.

Keywords:
19F MRI19F-MRI labelFluorineNMR spectroscopyperfluoro-tert-butyl groups

More Related Videos

Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging
08:12

Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging

Published on: March 20, 2013

11.9K
In vivo 19F MRI for Cell Tracking
10:05

In vivo 19F MRI for Cell Tracking

Published on: November 25, 2013

14.8K

Related Experiment Videos

Last Updated: Jul 25, 2025

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
09:57

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography

Published on: January 11, 2020

7.5K
Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging
08:12

Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging

Published on: March 20, 2013

11.9K
In vivo 19F MRI for Cell Tracking
10:05

In vivo 19F MRI for Cell Tracking

Published on: November 25, 2013

14.8K

Area of Science:

  • Medical Imaging
  • Biochemistry
  • Materials Science

Background:

  • 19F MRI is a non-ionizing radiation technique for in vivo tracking and quantification.
  • Existing 19F MRI labels have limitations in contrast or synthesis.

Purpose of the Study:

  • To report novel 19F MRI labels based on perfluoro-tert-butyl groups.
  • To evaluate their properties for in vivo imaging applications.

Main Methods:

  • Synthesis of 1,2-bis(perfluoro-tert-butoxy)ethane (C10 F18 H4 O2) and 1,3-bis(perfluoro-tert-butyl)propane (C11 F18 H6).
  • Preparation of 19F molecule emulsions.
  • In vivo 19F MRI studies in laboratory rats.

Main Results:

  • Both compounds contain a high percentage of 19F atoms (68.67% and 71.25%).
  • Demonstrated high contrast properties and good biological inertness in rats.
  • Rapid elimination observed, with complete clearance in approximately 30 days at a dose of 0.34 mg/g body weight.

Conclusions:

  • The novel 19F MRI labels are promising for in vivo imaging applications.
  • Ease of synthesis further supports their potential utility.
  • These compounds offer a viable alternative for non-ionizing radiation-based tracking and quantification.