[Correlation between the therapeutic effectiveness of corinfar and its dose in patients with exercise-induced...

A study of the antianginal efficacy of corinfar therapy by courses at daily doses of 30 and 60 mg (14 days) was carried out in 20 patients (males) with typical angina pectoris. Individual variability of response to the studied drug doses was noted. A high increment of tolerance to physical exercise on the bicycle ergometer was noted in the 1st group of patients using even small doses (30mg), in the 2nd group the antianginal effect was observed after increasing the dose up to 60 mg and in the 3rd group no effect was observed with any of the doses. Corinfar therapy did not influence the heart rate (HR), systolic and diastolic arterial pressure (SAP, DAP) and the double derivative (SAP X HR) at rest. A significant decrease in the above parameters as compared to the initial ones was noted in physical exercise at the level of the control test. At the maximum level of exercise the parameters corresponded to those of the initial test.