Syngeneic spleen cell immunization induces high mortality among progeny in mice

Syngeneic spleen cell immunization of C57BL/6J females prior to syngeneic matings resulted in significant perinatal and postnatal mortality and increased abnormality among progeny. Thus female recipients of transplants and transfusions from major histocompatibility complex (MHC) compatible donors might effect some risk to their progeny.