Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interaction between plasma factor XIII and collagen.

T Kikuchi, J Takagi, K Kasahara

    Thrombosis Research
    |July 15, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Development of a new antibody drug to treat congenital tooth agenesis.

    Journal of oral biosciences·2024
    Same author

    Advances in tooth agenesis and tooth regeneration.

    Regenerative therapy·2023
    Same author

    Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling.

    Science advances·2021
    Same author

    Measurement of jet activity produced in top-quark events with an electron, a muon and two <i>b</i>-tagged jets in the final state in <i>pp</i> collisions at [Formula: see text] TeV with the ATLAS detector.

    The European physical journal. C, Particles and fields·2017
    Same author

    Usefulness and capability of three-dimensional, full high-definition movies for surgical education.

    Maxillofacial plastic and reconstructive surgery·2017
    Same author

    Measurement of the prompt <i>J</i>/[Formula: see text] pair production cross-section in <i>pp</i> collisions at [Formula: see text] TeV with the ATLAS detector.

    The European physical journal. C, Particles and fields·2017
    Same journal

    Apoptotic versus procoagulant platelets: similar "necrotic" phenotype and procoagulant activity in vitro, but distinct adhesive protein composition.

    Thrombosis research·2026
    Same journal

    Heatstroke-induced coagulopathy: A scoping review of therapeutic strategies and outcome reporting.

    Thrombosis research·2026
    Same journal

    Mapping thrombus habitat: Non-contrast MRI radiomics and pixel-tile histomics approach to track venous thrombosis evolution in mice.

    Thrombosis research·2026
    Same journal

    A study protocol for a randomised controlled trial evaluating the safety and efficiency of the YEARS algorithm versus computed tomography pulmonary angiography only for suspected acute pulmonary embolism in patients with cancer: the Hydra Study.

    Thrombosis research·2026
    Same journal

    Associating the phenotypic expression of platelets with disease type through image-based single-cell profiling.

    Thrombosis research·2026
    Same journal

    The mechanisms of contractile dysfunction following chronic limited platelet activation in (pro)thrombotic conditions.

    Thrombosis research·2026
    See all related articles

    Plasma Factor XIII (FXIII) binding to collagen is hindered by a plasma protein complex. Researchers identified a 260,000 Mr protein that likely prevents FXIII-collagen interaction, impacting blood coagulation research.

    Area of Science:

    • Biochemistry
    • Hematology
    • Protein Chemistry

    Background:

    • Factor XIII (FXIII) is crucial for blood coagulation.
    • FXIII's interaction with collagen is important for clot stabilization.
    • Previous studies noted challenges in studying FXIII-collagen binding in plasma.

    Purpose of the Study:

    • To investigate the reasons behind Factor XIII's poor binding to collagen in plasma.
    • To identify potential plasma-binding partners of Factor XIII that impede collagen interaction.

    Main Methods:

    • Affinity chromatography using immobilized collagen.
    • Affinity chromatography using immobilized Factor XIII.
    • Analysis of protein interactions in plasma.

    Main Results:

    Related Experiment Videos

    • Purified Factor XIII efficiently bound to immobilized collagen.
    • Up to 80% of Factor XIII in plasma did not bind to the collagen column.
    • A protein with an apparent molecular weight of 260,000 was isolated from plasma using a Factor XIII affinity column.

    Conclusions:

    • A plasma protein complex, not protein covering, hinders Factor XIII binding to collagen.
    • A specific 260,000 Mr plasma protein forms a complex with Factor XIII, preventing its collagen interaction.
    • This finding has implications for understanding Factor XIII function in hemostasis.