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Exercise, particularly resistance training, boosts high-density lipoprotein (HDL) cholesterol. The APOE rs7412 gene variant influences this effect, with carriers of the CT+TT genotype showing greater HDL increases from exercise.

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Area of Science:

  • Cardiovascular Health
  • Genetics
  • Exercise Physiology

Background:

  • Exercise is linked to improved cardiometabolic health, including higher high-density lipoprotein (HDL) cholesterol levels.
  • Genetic factors, such as polymorphisms, may influence individual responses to exercise regarding HDL cholesterol.
  • The specific role of the APOE rs7412 gene variant in exercise-induced HDL changes requires further investigation.

Purpose of the Study:

  • To investigate the association between the APOE rs7412 gene variant, exercise, and HDL cholesterol levels.
  • To determine if the APOE rs7412 genotype modifies the relationship between different types of exercise and HDL cholesterol.
  • To analyze exercise-induced HDL cholesterol changes in relation to APOE rs7412 genotypes in a Taiwanese population.

Main Methods:

  • Utilized data from 57,638 normolipidemic adults in the Taiwan Biobank (TWB) collected between 2008 and 2019.
  • Employed multiple linear regression models to assess the interplay between exercise (aerobic and resistance), APOE rs7412 genotype (CC vs. CT+TT), and HDL cholesterol.
  • Categorized participants based on genotype and exercise status (no exercise, aerobic, resistance) for comparative analysis.

Main Results:

  • Both aerobic and resistance exercise were positively associated with higher HDL cholesterol levels.
  • Resistance exercise showed a stronger association with increased HDL cholesterol compared to aerobic exercise.
  • Individuals with the APOE rs7412 CT+TT genotype exhibited significantly higher HDL cholesterol levels in response to both aerobic and resistance exercise compared to the CC genotype, especially with resistance exercise.

Conclusions:

  • Self-reported aerobic and resistance exercise effectively increase HDL cholesterol levels.
  • Resistance exercise demonstrates a more pronounced effect on elevating HDL cholesterol.
  • The APOE rs7412 genotype plays a significant role in modulating exercise-induced HDL cholesterol changes, with the CT+TT genotype associated with greater benefits, particularly from resistance training.