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Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

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Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
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3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation
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Fabricating the cartilage: recent achievements.

Nesa Fani1,2, Maria Peshkova3, Polina Bikmulina3,4

  • 1Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

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|June 30, 2023
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Summary

Recent advancements in cartilage engineering utilize personalized bioprinted tissue equivalents for defect repair. These strategies, combining cell types, biomaterials, and bioreactors, show promise for clinical translation in cartilage restoration.

Keywords:
3D bioprintingCartilage regenerationHyaline cartilageSmart biomaterialsTissue engineering

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Cartilage defects pose significant clinical challenges.
  • Current treatments for cartilage damage have limitations.
  • Tissue engineering offers a promising approach for cartilage restoration.

Purpose of the Study:

  • To review recent achievements in cartilage engineering.
  • To provide insights into strategies for restoring cartilage defects.
  • To update the status of cartilage tissue fabrication techniques.

Main Methods:

  • Discussion of cell types, biomaterials, and biochemical factors for cartilage tissue formation.
  • Review of fabrication techniques used in cartilage engineering.
  • Focus on personalized product platforms including bioprinters, bioinks (ECM-embedded autologous cell aggregates), and bioreactors.
  • Exploration of in situ platforms for cartilage repair.

Main Results:

  • Integration of cell types, biomaterials, and biochemical factors enables the formation of cartilage tissue equivalents.
  • Advanced fabrication techniques, including bioprinting and bioreactors, are crucial for engineering cartilage.
  • Personalized, full-cycle platforms offer improved strategies for cartilage tissue restoration.
  • In situ platforms demonstrate potential for intraoperative tissue adjustment.

Conclusions:

  • Cartilage engineering is advancing rapidly with innovative fabrication techniques.
  • Personalized approaches using bioprinting and bioreactors are key to successful cartilage restoration.
  • While early-stage clinical translation is occurring, further preclinical and clinical trials are anticipated for engineered cartilage therapies.