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Altered intestinal microbiota in children with bronchiolitis.
Xiao-Bin Wu1,2, Jian Wang1,2, Yuan Tang1,2
1Chongqing Health Center for Women and Children, Chongqing, China.
Frontiers in Microbiology
|June 30, 2023
Summary
Children with bronchiolitis show altered gut microbiota, with fewer beneficial bacteria and increased Sphingomonas. Clostridium butyricum supplementation may help reduce RSV-induced lung inflammation.
Area of Science:
- Microbiology
- Pediatrics
- Immunology
Background:
- Bronchiolitis is a common respiratory infection in infants.
- The role of intestinal microbiota in pediatric diseases is increasingly recognized.
Purpose of the Study:
- To investigate the correlation between intestinal microbiota alterations and bronchiolitis in children.
- To identify potential microbial biomarkers for bronchiolitis onset.
Main Methods:
- Compared intestinal microbiota and metabolites in 57 children with bronchiolitis and 36 healthy children.
- Utilized high-throughput sequencing, untargeted metabolomics, and ELISA.
- Validated findings in a mouse model of RSV infection.
Main Results:
- Children with bronchiolitis had significantly lower alpha diversity (Shannon, Simpson, Pielou's evenness).
- Reduced abundance of short-chain fatty acid (SCFA)-producing bacteria (e.g., Firmicutes, Bacteroidetes, Clostridium) was observed.
- Increased abundance of Sphingomonas and elevated fecal amino acids were associated with bronchiolitis progression.
- Clostridium butyricum supplementation alleviated RSV-induced lung inflammation in mice.
Conclusions:
- Altered intestinal microbiota, decreased SCFAs, and elevated sphingolipids are linked to bronchiolitis progression in children.
- Specific fecal bacteria and metabolites may predict bronchiolitis onset.
- Oral Clostridium butyricum shows potential for alleviating RSV-induced pulmonary inflammation.
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