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Serum Laboratory Studies, Stool Test, Breath Test

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...

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Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

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Influence of Colorectal Cancer Risk Factors on Predictive Value of a Positive Multitarget Stool DNA Test.

Kaden R Narayani¹, Raj I Narayani

¹Gastrointestinal Associates, PC, Knoxville, TN.

Journal of Clinical Gastroenterology

|June 30, 2023

Summary

The multitarget stool-based DNA (mt-sDNA) test shows similar predictive value for colorectal cancer (CRC) in patients with and without known CRC risk factors. High adherence to follow-up colonoscopy was observed in this real-world study.

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Area of Science:

Gastroenterology
Oncology
Diagnostic Medicine

Background:

Multitarget stool-based DNA (mt-sDNA) testing is approved for colorectal cancer (CRC) screening in average-risk individuals.
The utility of mt-sDNA testing in patients with pre-existing CRC risk factors, such as a history of adenomatous polyps or family history of CRC, remains unclear.

Conclusions:

Adherence to diagnostic colonoscopy after a positive mt-sDNA test is high.
Pre-existing colorectal cancer risk factors do not alter the positive predictive value of the mt-sDNA test.