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Updated: Jul 25, 2025
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A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
Published on: June 10, 2020
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Infusible Extracellular Matrix Biomaterial Promotes Vascular Integrity and Modulates the Inflammatory Response in
Miranda D Diaz1,2, Rebecca M Kandell1,2, Jason R Wu1,2
1Shu-Chien Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Advanced Healthcare Materials
|June 30, 2023
Summary
An infusible extracellular matrix biomaterial (iECM) effectively reduced blood-brain barrier permeability and inflammation after traumatic brain injury (TBI) in mice, showing potential for TBI treatment.
Area of Science:
- Neuroscience
- Biomaterials Science
- Regenerative Medicine
Background:
- Traumatic brain injury (TBI) affects millions annually, often causing long-term disability.
- TBI leads to blood-brain barrier breakdown, increasing vascular permeability and injury progression.
Purpose of the Study:
- To investigate the potential of an infusible extracellular matrix-derived biomaterial (iECM) as a TBI treatment.
- To assess iECM's ability to reduce vascular permeability and modulate gene expression in injured brain tissue.
Main Methods:
- Characterized iECM pharmacokinetics and accumulation at the TBI site in a mouse model.
- Evaluated iECM's effect on molecular extravasation into the brain and trans-endothelial electrical resistance in vitro.
- Analyzed gene expression changes in brain tissue post-TBI and iECM treatment.
Main Results:
- Demonstrated robust iECM accumulation at the TBI site.
- Showed iECM reduced molecular extravasation and increased endothelial cell barrier integrity.
- Observed iECM downregulated proinflammatory responses and promoted neuroprotection at specific time points.
Conclusions:
- iECM exhibits potential as a therapeutic agent for traumatic brain injury.
- iECM effectively mitigates key pathological features of TBI, including blood-brain barrier disruption and neuroinflammation.
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