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Relationship between gene-environment interaction and obsessive-compulsive disorder: A systematic review
Lina Wang1, Yu Chen2, Miao Wang2
1Department of Psychology, Shandong Normal University, Jinan, Shandong, 250358, China; Department of Psychiatry, Shandong Mental Health Center, Shandong University, Jinan, Shandong, 250014, China.
Journal of Psychiatric Research
|June 30, 2023
Summary
Gene-environment interaction (G × E) influences obsessive-compulsive disorder (OCD) susceptibility and clinical traits. G × E
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Gene-environment interaction (G × E) describes how environmental factors alter genetic expression.
- G × E is implicated in the development of neuropsychiatric disorders, including obsessive-compulsive disorder (OCD).
Approach:
- A systematic review analyzed seven studies investigating G × E in OCD.
- The review examined seven specific genes, polygenic risk scores, childhood trauma, and stressful life events.
Key Points:
- G × E significantly increases susceptibility to OCD.
- G × E plays a critical role in OCD's clinical characteristics.
- The impact of G × E on OCD treatment response is inconsistent across studies.
Conclusions:
- Further research incorporating multi-omics and G × E into GWAS is essential for understanding OCD etiology.
- Integrating G × E insights may guide future therapeutic interventions for OCD.
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