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Published on: March 8, 2020
Phakellisins A-E, cyclopeptides from a marine sponge Phakellia sp. guided by LC-MS
Can Kong1, Ying Wu2, Hui-Min Zhao2
1Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Key Laboratory for Biosensor of Shandong Province, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, Shandong, People's Republic of China.
Abstract:
A chemical investigation of the marine sponge Phakellia sp. from the South China Sea yielded five new cyclopeptides, phakellisins A-E (1-5). Structures of these compounds were determined by comprehensive analysis of 1D/2D NMR, HRESIMS/MS spectroscopic data and the advanced Marfey's method. All compounds were evaluated for their cytotoxic activity. Compound 1 showed a strong inhibitory activity against WSU-DLCL-2 cells with an IC50 value of 5.25 ± 0.2 μM by induction of G0/G1 cell cycle arrest and apoptosis.

