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Role and therapeutic target of P2X2/3 receptors in visceral pain

Hong-Mei Luo1, Jia-Rong Ye2, Fan-Qin Pu1

  • 1Department of Rheumatology, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang City, Jiangxi province 343000, China.

Neuropeptides
|June 30, 2023
PubMed

Insights

The P2X2/3 receptor plays a key role in visceral pain (VP) development by enhancing nerve sensitivity and transmission. P2X2/3 antagonists show promise for effective VP targeted therapy.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Pain Research

Background:

  • Visceral pain (VP) pathogenesis is not fully understood, with limited effective treatments.
  • The P2X2/3 receptor's role in VP is an emerging area of research.
  • ATP release and P2X2/3 activation are implicated in visceral hypersensitivity.

Purpose of the Study:

  • To review the biological functions of the P2X2/3 receptor.
  • To elucidate the link between P2X2/3 and visceral pain.
  • To discuss the therapeutic potential of P2X2/3 antagonists for VP.

Main Methods:

  • Literature review focusing on P2X2/3 receptor function and VP.
  • Analysis of signaling pathways involving ATP and P2X2/3 in visceral nociception.
  • Evaluation of pharmacological data on P2X2/3 antagonists in VP models.

Main Results:

  • P2X2/3 activation enhances peripheral receptor sensitivity and neuronal plasticity.
  • P2X2/3 signaling contributes to central nervous system sensitization in VP.
  • P2X2/3 antagonists demonstrate pain-relieving effects.

Conclusions:

  • P2X2/3 is a significant mediator in the development of visceral pain.
  • Targeting P2X2/3 with antagonists offers a promising therapeutic strategy for VP.
  • Further research into P2X2/3 antagonists can provide a basis for novel VP treatments.
Keywords:
Adenosine triphosphate (ATP)AntagonistsP2X2/3Visceral pain (VP)

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