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Updated: Jul 25, 2025

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
Dispersed differential hunger games search for high dimensional gene data feature selection
Zhiqing Chen1, Li Xinxian2, Ran Guo3
1School of Intelligent Manufacturing, Wenzhou Polytechnic, Wenzhou, 325035, China.
Abstract:
The realms of modern medicine and biology have provided substantial data sets of genetic roots that exhibit a high dimensionality. Clinical practice and associated processes are primarily dependent on data-driven decision-making. However, the high dimensionality of the data in these domains increases the complexity and size of processing. It can be challenging to determine representative genes while reducing the data's dimensionality. A successful gene selection will serve to mitigate the computing costs and refine the accuracy of the classification by eliminating superfluous or duplicative features. To address this concern, this research suggests a wrapper gene selection approach based on the HGS, combined with a dispersed foraging strategy and a differential evolution strategy, to form a new algorithm named DDHGS. Introducing the DDHGS algorithm to the global optimization field and its binary derivative bDDHGS to the feature selection problem is anticipated to refine the existing search balance between explorative and exploitative cores. We assess and confirm the efficacy of our proposed method, DDHGS, by comparing it with DE and HGS combined with a single strategy, seven classic algorithms, and ten advanced algorithms on the IEEE CEC 2017 test suite. Furthermore, to further evaluate DDHGS' performance, we compare it with several CEC winners and DE-based techniques of great efficiency on 23 popular optimization functions and the IEEE CEC 2014 benchmark test suite. The experimentation asserted that the bDDHGS approach was able to surpass bHGS and a variety of existing methods when applied to fourteen feature selection datasets from the UCI repository. The metrics measured--classification accuracy, the number of selected features, fitness scores, and execution time--all showed marked improvements with the use of bDDHGS. Considering all results, it can be concluded that bDDHGS is an optimal optimizer and an effective feature selection tool in the wrapper mode.
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