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Falsely decreased vancomycin caused by rheumatoid factor: A case report.
Mai Elzieny1, Jordan A Fisher2, Matthew D Sims3
1Department of Pathology and Laboratory Medicine, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA.
Rheumatoid factor can cause falsely low vancomycin levels in lab tests, leading to potential overtreatment. Prompt identification and retesting using alternative methods are crucial for patient safety and avoiding vancomycin toxicity.
Area of Science:
- Clinical Chemistry
- Immunology
- Pharmacology
Background:
- Vancomycin therapy requires monitoring of trough concentrations due to potential nephrotoxicity.
- Falsely decreased vancomycin measurements can lead to inappropriate dosing and increased risk of toxicity.
- Accurate therapeutic drug monitoring is essential for optimizing patient outcomes.
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