Global biomarker trends in Alzheimer's research: A bibliometric analysis

Alzheimer's disease (AD) has no effective treatment, although antibody drugs targeting beta-amyloid, mainly aducanumab, have produced useful clinical results. Biomarkers can be used to determine drug regimens effectively and to monitor the effects of drugs. A concept in which biomarkers reflect disease states is emerging. Although several AD biomarker studies have been reported, measurement methods and target molecules are still being validated, and various biomarkers are being explored. This study analyzed trends in research on AD biomarkers using bibliometric methods, revealing an exponential increase in research reports in this field, with the US most active in research. Analysis of the 'Burst' biomarkers using CiteSpace revealed that networks centered on authors, rather than networks among countries, drive new research trends in this area.