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Updated: Jul 25, 2025

Antibiotic Dereplication Using the Antibiotic Resistance Platform
Published on: October 17, 2019
Towards new antibiotics classes targeting bacterial metallophores
Zeinab Ezzeddine1, Ghassan Ghssein1
1Laboratory Sciences Department, Faculty of Public Health, Islamic University of Lebanon (IUL), Khalde P.O. Box, 30014, Lebanon; Faculty of Sciences V, Lebanese University, Nabatieh, 1700, Lebanon.
Abstract:
The increasing bacterial resistance caused by antibiotic overuse has promoted the search for new antimicrobial strategies. Metals uptake via bacterial metallophores are studied to develop new therapeutics against infectious diseases, because metal ions are essential for bacterial growth and virulence. Metal ions assimilation is mainly dependent on metallophores production which are metal chelators synthetized and produced by bacteria to facilitate metals uptake and are vital for bacterial pathogenicity. Here we highlight the perspective for antimicrobial and therapeutic potential of metallophores through several approaches for metallophores application in antimicrobial therapy.
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