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Cyclosporine-induced erythromelalgia
Francisco Caiza-Zambrano1, Julio Galarza2, Mauricio Benetti2
1Department of Neurology, Hospital Británico de Buenos Aires, Buenos Aires, Argentina pancho_jcz@hotmail.com.
Practical Neurology
|June 30, 2023
Summary
Erythromelalgia, a rare condition causing extremity pain and redness, can be a side effect of cyclosporine treatment for myasthenia gravis. This adverse drug reaction is reversible, highlighting the need for clinical awareness.
Area of Science:
- Neurology
- Pharmacology
- Dermatology
Background:
- Erythromelalgia is a rare syndrome with symptoms of erythema, heat, and burning pain in the extremities.
- It presents in primary (genetic) and secondary (toxic, drug-related, or disease-associated) forms.
Observation:
- A 42-year-old woman with myasthenia gravis developed erythromelalgia.
- The condition emerged after initiating cyclosporine therapy for her myasthenia gravis.
Findings:
- Cyclosporine use was associated with the onset of erythromelalgia in this patient.
- The exact mechanism linking cyclosporine to erythromelalgia remains unclear.
- Concurrent use of corticosteroids may exacerbate cyclosporine's toxic effects.
Implications:
- This case highlights a rare but reversible adverse effect of cyclosporine.
- Clinicians should consider erythromelalgia in patients taking cyclosporine, particularly those with myasthenia gravis.
- Awareness of this association is crucial for timely diagnosis and management.
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