Progress on Physical Field-Regulated Micro/Nanomotors for Cardiovascular and Cerebrovascular Disease Treatment
Qing You1, Xinyue Shao2, Jinping Wang2
1Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore, 119074, Singapore.
Insights
Physical field-regulated micro/nanomotors offer targeted treatment for cardiovascular and cerebrovascular diseases (CCVDs). These advanced motors enhance drug delivery and therapeutic efficiency, overcoming traditional treatment limitations.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cardiovascular Medicine
Background:
- Cardiovascular and cerebrovascular diseases (CCVDs) are leading causes of global mortality and disability.
- Conventional CCVD treatments lack specificity, potentially causing off-target organ damage.
- Micro/nanomotors offer autonomous movement for enhanced drug delivery and lesion site interaction.
Purpose of the Study:
- To review physical field-regulated micro/nanomotors for treating CCVDs.
- To highlight recent advances in this therapeutic approach.
- To discuss challenges and future directions in the field.
Main Methods:
- Review of literature on physical field-driven micro/nanomotors.
- Focus on magnetic field, light, and ultrasound-regulated motors.
- Analysis of their application in CCVD treatment.
Main Results:
- Physical field-regulated micro/nanomotors demonstrate enhanced penetration and retention at lesion sites.
- These motors provide efficient therapeutic effects with intelligent control capabilities.
- They represent a promising alternative to conventional CCVD therapies.
Conclusions:
- Physical field-regulated micro/nanomotors are emerging as effective tools for CCVD treatment.
- Further research is needed to address current challenges and optimize their clinical application.
- These technologies hold significant potential for patient-friendly and precise CCVD interventions.
Abstract:
Cardiovascular and cerebrovascular diseases (CCVDs) are two major vasculature-related diseases that seriously affect public health worldwide, which can cause serious death and disability. Lack of targeting effect of the traditional CCVD treatment drugs may damage other tissues and organs, thus more specific methods are needed to solve this dilemma. Micro/nanomotors are new materials that can convert external energy into driving force for autonomous movement, which can not only enhance the penetration depth and retention rates, but also increase the contact areas with the lesion sites (such as thrombus and inflammation sites of blood vessels). Physical field-regulated micro/nanomotors using the physical energy sources with deep tissue penetration and controllable performance, such as magnetic field, light, and ultrasound, etc. are considered as the emerging patient-friendly and effective therapeutic tools to overcome the limitations of conventional CCVD treatments. Recent efforts have suggested that physical field-regulated micro/nanomotors on CCVD treatments could simultaneously provide efficient therapeutic effect and intelligent control. In this review, various physical field-driven micro/nanomotors are mainly introduced and their latest advances for CCVDs are highlighted. Last, the remaining challenges and future perspectives regarding the physical field-regulated micro/nanomotors for CCVD treatments are discussed and outlined.
