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Changes in Perception of Cure Among Patients With Genitourinary Cancers Initiating Immune Checkpoint Inhibitors: A
Cristiane Decat Bergerot1, Errol J Philip2, Ameish Govindarajan3
1Centro de Cancer de Brasilia, Instituto Unity de Ensino e Pesquisa, Oncoclinicas, Brasília, DF, Brazil.
Clinical Genitourinary Cancer
|June 30, 2023
Summary
Patients with genitourinary cancers receiving immune checkpoint inhibitors (ICIs) develop more accurate expectations of cure over time. This improved expectation correlates with reduced anxiety and better outcomes.
Area of Science:
- Oncology
- Immunotherapy
- Patient-Reported Outcomes
Background:
- Genitourinary (GU) cancers are a significant health concern.
- Immune checkpoint inhibitors (ICIs) represent a novel treatment modality for GU cancers.
- Understanding patient perceptions of cure during ICI therapy is crucial.
Purpose of the Study:
- To investigate changes in patients' expectations of cure while undergoing ICI therapy for GU cancers.
- To assess the relationship between expectation of cure and anxiety levels.
- To explore the association between expectation of cure and treatment side effects.
Main Methods:
- A longitudinal study design was employed.
- Patients were assessed at baseline and 3 months post-therapy initiation.
- Questionnaires included ICI perception, PROMIS Anxiety scale, and expectation of cure; statistical analyses included general linear modeling and chi-square tests.
Main Results:
- The proportion of patients with an accurate expectation of cure increased significantly over time (55.6% to 66.7%, P = .001).
- Accurate expectation of cure was linked to lower anxiety levels.
- Inaccurate expectation of cure correlated with more severe side effects and worse ECOG scores.
Conclusions:
- Patients with GU metastatic cancer treated with ICI therapy show progressively accurate expectations of cure.
- Accurate expectations of cure are associated with decreased anxiety.
- Further research is warranted to develop interventions supporting accurate expectation formation.
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