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Pathophysiological roles of thrombospondin-4 in disease development
1Department of Anesthesiology & Perioperative Care, School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
Seminars in Cell & Developmental Biology
|June 30, 2023
Summary
Thrombospondin-4 (TSP-4) is a key extracellular matrix protein involved in cell interactions and tissue development. Its dysregulation contributes to various diseases, highlighting its potential as a therapeutic target.
Area of Science:
- Biochemistry
- Cell Biology
- Extracellular Matrix Research
Background:
- Thrombospondin-4 (TSP-4) is an extracellular matrix glycoprotein with a unique pentameric structure.
- TSP-4 interacts with various matrix components, proteins, and signaling molecules.
- Its functions are critical in physiological processes and implicated in pathological conditions.
Purpose of the Study:
- To review recent findings on TSP-4's role in physiological and pathological conditions.
- To elucidate the unique functions of TSP-4 compared to other thrombospondins.
- To explore TSP-4's potential as a diagnostic or therapeutic target.
Main Methods:
- Literature review of existing research on Thrombospondin-4.
- Analysis of TSP-4's structure-function relationship.
- Synthesis of data on TSP-4's involvement in development and disease.
Main Results:
- TSP-4 mediates crucial processes like cell adhesion, migration, proliferation, tissue remodeling, angiogenesis, and synaptogenesis.
- Maladaptation of TSP-4-mediated processes is linked to skeletal dysplasia, osteoporosis, cardiovascular diseases, and neurological disorders.
- TSP-4's distinct characteristics set it apart from other thrombospondins.
Conclusions:
- TSP-4 plays a significant role in diverse physiological and pathological processes.
- Dysregulated TSP-4 function contributes to the pathogenesis of multiple diseases.
- TSP-4 represents a promising target for future therapeutic and diagnostic strategies.
Keywords:
AngiogenesisCalcium-bindingCancer growthCardiovascular diseasesExtracellular matrix glycoproteinInflammationMetastasisNociceptionSynaptogenesisThrombospondin-4More Related Videos
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